Live long and prosper: germline stem cell maintenance revisited (retrospective on DOI: 10.1002/bies.201000085).
نویسنده
چکیده
In many animals there is an apparent trade-off between reproduction and lifespan. Reproductive capacity is often determined by germ line stem cell (GLSC) function. These cells undergo self-renewing divisions to give rise to a gametogenic daughter cell that differentiates into one or more gametes, and a stem cell daughter that remains in the stem cell niche. If GLSC aging is slow or their mitoses are biased towards self-renewing conditions, then theymay last longer and enable animals to undergo late-life reproduction, associated with increased longevity. In contrast, if GLSC aging is rapid or their divisions tend to produce gametogenic daughters, then they may limit animals with such cells to early-life reproduction and shortened lifespan. Kazmarczyk and Kopp recently suggested that variation in GLSC maintenance may mediate this trade-off. Their hypothesis predicts that allelic variation in GLSC genes in short-lived strains would show bias towards “short term alleles” driving high, early-life expression of GLSC maintenance genes; in long-lived strains, “long term alleles” driving high, late-life expression of stem cell maintenance genes would predominate [1]. However, female flies from a longlived lineage show little change over their lifespan in expression levels of genes associated with oogenesis and stem cell division: they do not downregulate these genes with age, in contrast to shorterlived control females [2]. Moreover, there was no clear overlap between the results of this next generation sequencing study and an independent microarray-based
منابع مشابه
Going retro: Transposable elements, embryonic stem cells, and the mammalian placenta (retrospective on DOI 10.1002/bies.201300059).
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عنوان ژورنال:
- BioEssays : news and reviews in molecular, cellular and developmental biology
دوره 35 9 شماره
صفحات -
تاریخ انتشار 2013